C-reactive protein (CRP) has been known to be associated with vascular inflammation and hypertension. Pulse wave velocity (PWV) increases according to the degree of the arterial stiffness in hypertension patients. Therefore, PWV may be correlated with CRP levels in treated hypertensive patients, irrespective of medication. We sought to determine whether there is a correlation between hsCRP and arterial stiffness in non-diabetic treated hypertensive patients, independent of cardiovascular risk factor.
This study consisted of 487 non-diabetic patients at least 40 years-old who were being treated for hypertension. At the time of enrollment, the patients underwent a baseline laboratory assessment of C-reactive protein levels and pulse wave velocity (PWV). Heart to femoral PWV (hfPWV) and brachial to ankle PWV (baPWV) were used as a marker of arterial stiffness.
Subjects were categorized according to tertiles of hsCRP level [Group 1: 1st tertile (0.20 – 0.45 mg/L), Group 2: 2nd tertile (0.46 - 1.12 mg/L), Group 3: 3rd tertile (1.15 - 9.71 mg/L)]. Group 1 consisted of 160 patients (mean age 56 ± 4 years), Group 2 had 165 patients (mean age 57 ± 9 years) and Group 3 had 162 patients (mean age 60 ± 9 years). The hfPWV and baPWV increased significantly along with the hsCRP level. Group 1 had an hfPWV and baPWV of 949 191, 1433 240 cm/sec, respectively, Group 2 was 962 166, 1467 246 cm/sec and Group 3 was 1021 208, 1542 253 cm/sec (p < 0.01). The hfPWV also showed a strong correlation with baPWV (r=0.695, p < 0.001). The hsCRP level was independently associated with arterial stiffness (hfPWV: R2=0.265, p < 0.001, baPWV: R2=0.289, p = 0.001) after controlling for age, body mass index, systolic blood pressure (BP), heart rate, gender, HDL-cholesterol, triglyceride, glucose level and medications.
In conclusion, hsCRP was associated with arterial stiffness, independent of age, systolic BP, gender, heart rate, glucose, lipid profiles and medications in treated hypertension. Therefore, hsCRP could be a useful marker of arterial stiffness in treated hypertension patients and a possible target for arterial inflammation in hypertension.
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