Background: Both endothelial dysfunction and arterial stiffness are involved in the pathogenesis of atherosclerosis and are well known as risk factors of cardiovascular morbidity and mortality. The aim of this study was to evaluate the effects of calcium channel blocker (CCB: Cilnidipine) and angiotensin converting enzyme inhibitor (ACEI: captopril) on endothelial function measured by flow mediated vasodilation (FMD) of brachial artery and arterial stiffness pulse wave velocity (PWV) in patients with angina pectoris. Methods: Eighty patients with angina pectoris (57.8짹9.9 years old, 50 males) were divided into CCB group (group I: n=41, 58.1짹9.7 years old, 21 males) and CCB plus ACEI group (group II: n=39, 57.5짹10.4 years old, 29 males). FMD and PWV were measured at baseline and 6 months after medical therapy. Results: Baseline FMD and PWV were not different between the groups at baseline. After 6 months of medical treatment, FMD were significantly improved in group II (7.5짹3.8 % to 8.7짹4.1%, p=0.04), but not in group I (8.1짹4.2 % to 8.0짹3.7 %, p=0.92). Brachial-ankle PWV were significantly improved in both groups (1797.7짹357.3 to 1534.9짹321.9 cm/s in group I, p=0.004, 1620.1짹288.2 to 1456.1짹191.5 cm/s in group II, p=0.006). However, heart-femoral PWV was significantly improved only in group II (1060.9짹250.4 to 971.3짹210.7 cm/s, p=0.04), but not in group I (1050.3짹239.6 to 996.8짹220.5 cm/s, p=0.09). Conclusion: Combination therapy of CCB and ACEI improves more effectively endothelial function and arterial stiffness than CCB mono-therapy in patients with angina pectoris.