학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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Non-invasive studies for atherosclerosis and endothelial function – Their relationships and the effects of risk factors
서울대학교병원 의과대학 내과학교실¹
신동호¹, 권동아, 정진욱, 최수연, 박진식, 김효수, 손대원, 오병희, 박영배, 최윤식¹
Background & Objectives ; The Carotid intima-media thickness (IMT), flow-mediated brachial artery dilation (FMD), aortic pulse wave velocity (PWV), ankle-brachial index (ABI) are representative of non-invasive tests for atherosclerosis and endothelial function. We evaluated these parameters for their correlations, and their associations with atherosclerosis risk factors. Subjects & Methods ; 168 people who received the ‘carotid ultrasound and vascular function tests’ in ‘SNUH Healthcare System’(ie. without definite specific symptoms) during November, 2003 ~ June, 2005 were enrolled. (118 men, mean age ; 55YO). The ‘carotid ultrasound and vascular function tests’ consisted of IMT, FMD, PWV, ABI. Results ; IMT and PWV showed a strong correlation (r=0.439, P<0.001) and FMD showed weak relations with others. (r=-0.188, P=0.015 with IMT, r=-0.178, p=0.023 with PWV) ABI was not associated with the others. Correlation with IMT and PWV were remained still (r=0.378, p<0.001) after controlling for the effect of hypertension and age, while those of FMD and others disappeard. Hypertension and systolic blood pressure were independent factors of increased IMT and PWV in multivariate analysis. Diabetes, Hb A1c and fasting blood glucose are associated with increased IMT. FMD also decresed in high Hb A1c and hyperglycemia, but not in diabetes group. Smoking was independent risk factors on increased IMT, but lipid had no effect on those parameters. Conclusion ; IMT and PWV had a strong relationship regardless of risk factors. FMD and ABI showed a weak or no correlation with the others in this study. There should be more studies with symptomatic patients. Each risk factors contributed to aortic stiffness, endothelial function as different degrees. It suggests there are different mechanisms of each factors in progression of atherosclerosis.


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