학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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ǥ : ȣ - 490853   247 
MADIT II Criteria and Other Non-invasive Parameters for Predicting Sudden Cardiac Death in Korean Post Myocardial Infarction Patients.
Cardiovascular Division, Yeungnam University Hospital, Daegu, South Korea
JW Sohn, DG Shin, SH Lee, JH Bae, HJ Kim, HS Cho, JH Kang, GR Hong, JS Park, YJ Kim, BS Shim, HS Cho, DH Lee
Background:According to Multicenter Automatic Defibrillator Implantation Trial (MADIT)II criteria, post MI patients whose left ventricular ejection fraction(LVEF) lower than 30%(high risk for sudden cardiac death(SCD)) indicated for ICD implantation. Other non-invasive parameters derived from Holter and signal-averaged ECG(SAECG) are known to have predictive value for SCD risk. However, data about prevalence of SCD risk factors and associated mortality rate of Kore-an post MI patients are lacking in the era of prophylactic ICD implantation for primary prevention of SCD. Objectives:The aim of study is to reveal the inciden-ce and the prognostic value of noninvasive parameters and whether MADIT II crit-eria for ICD implantation is appropriate in Korean PMI patients. Methods:During the period 2001 to 2005, 640 PMI survivors underwent echocardiography, Holter ECG and SAECG before discharge were selected. The incidence of abnormal SAECG, premature ventricular complex(PVC) counts>10/hr, non-sustained VT and VT on Holter ECG, and low(≤30%) LVEF were studied and used as risk stratification markers for later adverse arrhythmic events defined as VT, ventricular fibrillation and/or SCD. Results:The incidence of PVCs>10/hr was 13.6%(73/535), and NSVT or VT on Holter ECG was 7.3%(39/535).39 of 272(14.3%)had late potential on SAECG. Patients who have LVEF less than 30% were 4.4%(25/571). The SCD or adverse arrhythmic events were occurred in 5.9%(38/640)during 20.9±16.1 months of mean follow-up. Of 73 patients with PVCs>10/hr, 14 patients(19.2%); and of 39 patients with NSVT/VT episodes, 6 patients(19.2%)suffered from arrhythmic events(p<0.05). Arrhythmic events were occurred in 9 (31.0%) among 29 patients with lower LVEF(p<0.05). Of 29 patients with MADIT II characteristics, 8 patients(27.6%) died, which was larger than that of conventi-nal therapy group of MADIT II study despite similar age and LV function. The presence of late potential did not predict the events.Conclusion: Frequent PVCs(>10/hr) and LVEF less than 30% have a significant prognostic value for SCD risk stratification. MADIT II criteria and abnormal Holter ECG findings can be suggested as an indication for implanting ICD in Korean PMI patients.


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