Objective: We sought to evaluate the safety and effectiveness of paclitaxel-eluting stent(PES) for treatment of chronic total occlusion(CTO). Background: Percutaneous coronary intervention(PCI) of CTO is one of the major challenges in interventional cardiology due to relatively low procedural success rate and high incidence of restenosis and reocclusion compared with PCI of non CTO lesion. There are few published data on the safety and effectiveness of PES in treatment of CTO. Method: Elective PES implantation for CTO of greater than or equal to 3 months of duration with TIMI 0 flow was performed from July, 2003 to June, 2005. 34 lesions of 33 patients were enrolled. The primary end points are angiographic late luminal loss(LLL) and binary restenosis at 3 months and 12 months. Secondary end points are in hospital outcomes and major adverse cardiac events(MACE). Coronary artery aneurysm was defined as areas of localized coronary artery dilatation with a diameter greater than 1.2 times that of the adjacent normal reference segment. Result: The mean duration of CTO is 20.5 months. The length of CTO and the stents are 11.68 짹 10.41 mm and 46.00 짹 22.34 mm respectively. The mean number of stents used per lesion is 1.58. Until now 3 months follow up coronary angiographies were performed for 16 lesions of 15 patients. In stent LLL is 0.16 짹 0.38 mm. Binary restenosis rate at 3 months is 12.5% (2/16 lesions). 3 aneurysms were noted. There were no incidence of death, stent thrombosis, Q-wave myocardiac infarction, or emergent bypass surgery during hospitalization and until now. Conclusion: PES implantation for CTO might be effective for preventing restenosis in early follow up angiography and safe with regard to short and medium term complications.