Background : Drug eluting stent(DES) significantly reduced the rate of restenosis after stent inplantation. But, Few datas of DES for unprotected left main coronary artery(ULMCA) stenosis are clinically available. Therefore, we investigated superiority of DES compared with Bare metal stent(BMS) implantation for treatment of ULMCA stenosis. Method : From June 1996 to February 2005, 78 consecutive patients (BMS group : 56 patients-63 stents, DES group : 22 patients-30 stents) were followed up longer than 6months. The primary endpoint was cumulative major cardiac adverse events(MACE). The secondary end point was 6 month angiographic restenosis rate(RS). Results : There were no deference in baseline characteristics between the 2 groups. The procedural success rate was achieved in 100% of patients and no MACE during 30days in both group. During 42 짹 22months follow-up, there were 20 MACE(BMS : n = 18, 32.1 %, DES : n = 2, 9.1 %, p=0.036), 4 deaths(BMS : n=3, 5.4%, DES : n = 1, 4.5 %p= 0.884), 3 myocardial infarction (BMS : n = 3, 5.4 %, DES : n = 0, p = 0.268), 13 target lesion revascularization (BMS : n = 12, 21.4 %, DES : n = 1, 4.5%, p = 0.072), including 8 CABG(8 BMS) and 5 repeated PCI (4 BMS, 1 DES). Six month angiographic follow-up were done in 42 patients(BMS : n =34, 60.7%, DES : n =9, 40.9%, p = 0.151). There were 17 angiographic restenosis(BMS : n =16, 47.1 %, DES : n = 1, 11.1 %, p = 0.050). In BMS group, RS at distal bifurcation was significant high compared to DES group. (BMS : n = 8/12, 66.7 %, DES : n = 1/6, 16.7 %, p = 0.046). Conclusion : Coronary stenting with DES for ULMCA stenosis was fesible, safe and showed clinical outcome and reduction of angiographic restenosis, especially in distal left main bifurcation lesion.