학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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Plasma N-Terminal Pro-Brain Natriuretic Peptide Level at 6 Months after Percuatenous Coronary Intervention with Myocardial Infarction ; Correlation with Echocardiographic Parameters and Predicting Factors
Division of Cardiology, Internal Medicine, Yeungnam University Hospital, Daegu, Korea
Hyun-Su Cho, , Jong-Seon Park, Dong-Gu Shin, Gu-Ru Hong, Hyung-Jun Kim, Jun-Ho Bae, Young-Jo Kim, Bong Sup Shim
Background: N-terminal-proBNP (NT-proBNP) is an useful biomarker in the diagnosis and prediction of the prognosis in patients with heart failure or left ventricular dysfunction. The aim of this study was to evaluate the correlation between NT-proBNP levels and echocardiographic parameters and contributing factors for high NT-proBNP level in post-myocardial infarction (MI) patients. Method: NT-proBNP was measured in patients who visited for the follow up coronary angiography at 6 months after percutaneneous coronary intervention (PCI) associated with myocardial infarction and angina (as a control). Cardiac function was evaluated by echocardiography before PCI and after 6 months. Results; NT-proBNP was higher in patients with MI than angina (177±198 vs 63±54 pg/ml, p=0.004). NT-proBNP was correlated with left ventricular ejection fraction (LVEF) (r=-.436, p<0.001), wall motion score index (WMSI) (r=.440, p<0.001), left ventricular end-diastolic dimension (LVEDD) (r=.306, p=0.015) and left ventricular end-systolic dimension (LVESD) (r=.394, p=0.001). For the detection of LVEF<50% with NT-proBNP>200 ng/dl, positive predictive and negative predictive values were 57% and 83% respectively. On multivariate regression analysis, age, ST-elevated MI, WMSI and LVEF were associated with NT-proBNP higher than 200 ng/dl. Conclusions: NT-proBNP is a useful biomarker reflecting cardiac function and remodeling parameters in post-MI patients.
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