Background: Adiponectin is an adipocytokine which has anti-atherogenic and anti-inflammatory properties. Also, decreased adiponectin level is an independent predictor for the development of acute coronary syndrome. We investigated the adiponectin dynamics in patients with acute coronary syndrome. Method: Plasma concentrations of adiponectin were measured at the time of admission and after 6 weeks in 49 patients (age 59짹13 years) who admitted with acute coronary syndrome (ACS). To see the early recovery, adiponectin levels were also measured at admission and after 3, 4, 7 days and 6 weeks. We also measured body fat mass and severity of coronary artery disease. Results; Plasma concentrations of adiponectin correlated positively with age (r=0.355, p=0.012), but correlated negatively with body fat mass (r=0.296, p=0.039). No correlation was observed between adiponectin and severity of coronary artery disease. Decreased adiponectin level didn���t change during 7 days after admission. After 6 weeks, adiponectin levels were decreased or not changed in 26 patients (53%), but increased more than 1 ug/dl in 23 patients (47%). Conclusions: Decreased plasma adiponectin levels in patients with ACS recovered with time.