Background and Methods We previously reported safety and efficacy of drug eluting stent(DES)in'Real World'practice. Now we summarized two years'registry data and investigated changes of routine practice after introduction of DES at the interval of six months Results Between Mar2003 and Feb2005,1308pts/1795 lesions were treated with DES,34.3%DM,70.1%multivessel ds,55.9%ACS,71.9%complex(ACC/AHA class B2/C)lesions,5.24%chronic total occlusions,8.86 %in-stent restenosis,18.2%bifurcation and 3.73%left main lesions were included.Mean target vessel reference diameter and %DS was 2.88짹0.44mm and 82.5 짹 14.3%. Stents/lesion and total length of DES/lesion were 1.18 짹0.52/lesion and 29.7짹15.0mm.During follow up,documented SST and cumulative rate of MACE(mortality, MI or TLR)was 1% and 9.02%.In the angiography at 6 months,mean late loss was 0.28짹0.61mm.We divided pts into 4 subgroups according to the date of PCI and analyzed clinical/angiographic variables in each period.Application of DES is in the course of increase and demographic characteristics were not different in each period.DES was used in complex lesions in the early periods,but expanded its territory to simple lesion after insurance coverage and application of DES in ACS pts increased in the late period and this may be due to favorable short term result of randomized trials.Conclusion DES has shown excellent results after two yrs���run-in period and expanded its application under the support of accumulated clinical experiences and insurance coverage.