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ȣ - 490773 35 |
The Value of Low-Dose Dobutamine Stress MR as Prediction of
Functional Recovery after Revascularization: Comparison with DE-MRI
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Department of Diagnostic Radiology¹, Internal Medicine², Thoracic Surgery³, Seoul National University Bundang Hospital, Seoul National University College of Medicine |
Sang Il Choi¹, Hyuk-Jae Chang², Young-Seok Cho², Tae-Jin Youn², Woo-Young Chung², In-Ho Chae², Dong-Ju Choi², Cheol-Ho Kim², Cheong Lim³, Whal Lee¹, Jae Hyung Park¹ |
Purpose: To evaluate the feasibility of low-dose dobutamine stress MRI (DSMR) and comparative diagnostic values of low-dose DSMR and delayed contrast-enhanced MRI (DE-MRI) for predicting functional recovery in patients with dysfunctional myocardium at rest.
Materials and Methods: 52 patients underwent cine MR imaging at rest and low-dose DSMR from January 2004 to December 2004. In 18 patients with dysfunctional myocardium, wall motion was evaluated semiquantitatively by MRI before and 3 months after revascularization. All patients underwent steady-state cine MRI covering the entire left ventricle at rest and during low-dose DSMR (10µg/kg/min). DE-MRI was acquired to determine transmural extent of hyperenhancement. Follow-up cine MR images in the resting state were obtained 3 months after revascularization. On stress studies, myocardial segment was classified as reversible when systolic wall thickening was improved by >20% with dobutamine stress. On DE-MRI, myocardial segment was defined as reversible when the transmural extent of hyperenhancement was assessed by 0-50%.
Results: On the first cine MR images in the resting state, 142 (49.3%) of 288 segments demonstrated abnormal, regional contraction (systolic wall thickening <40%). Of the 70 segments showing functional recovery on the following cine MRI, 62 (89%) segments were recognized as reversible by low-dose DSMR and 59 (82%) segments by DE-MRI. The sensitivity, specificity, positive predictive value, and negative predictive value of low-dose DSMR was 89%, 92%, 91%, and 89%, respectively. These values of De-MRI were 82%, 63%, 69%, and 80%, respectively.
Conclusion: Low-dose dobutamine stress MRI can provide more accurate assessments for predicting regional functional recovery in comparison with delayed contrast-enhanced MRI in patients with ischemic heart disease who underwent revascularization.
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