Background : Peroxisome proliferators-activated receptors(PPARs) are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. PPARs have been implicated many disease related process including lipid metabolism, inflammation, embryo implantation, diabetes. Unlike PPAR-慣 and –款 receptors, little is known about the physiological role of PPAR-灌 isoform. The aim of this study is to investigate the effect of PPAR灌 genetic polymorphisms on coronary artery disease(CAD) Methods: c.-13454G>T, c.-877T>C, c.2022+12G>A, c.2629T>C were genotyped in 468 men who had absence of coronary artery disease(CAD, n=89) or one-(n=180), two-(n=127), three-vessel disease(n=93).Among 6 common haplotypes(frequency>0.025), most frequent 2 haplotypes was used for analysis(ht1, ht2, table). Results: 1 single genetic polymorphisms were not associated with CAD. 2. The frequency of ht1 and ht2 was 0.69 and 0.23 respectively. 3. Subjects with homozygous for ht1 were overexpressed in multivessel diseased compared with the subject with ht1/ht2, ht2/ht2 genotype in dose dependent manner(��2= 6.277, p=0.026). 4. By multivariate logistic regression analysis, the genotype of homozygous for ht1 was associated with independently and significantly increased risk of multivessel disease(p= 0.020, odds ratio=1.66[95% confidence interval, 1.085-2.536]) after adjusting age. Conclusion : PPAR灌 genetic polymorphism is associated with coronary artery disease especially multivessel disease in Korean men.