Objective: We compared the metabolic profiles and risk of coronary artery disease (CAD) in Koreans with non-diabetic metabolic syndrome(MetS) when applying the 4 criterias of MetS.[The NCEP criteria, Asian modified NCEP(a-NCEP) criteria, WHO criteria, Asian modified WHO(a-WHO)]. Research Design and Methods: The study group composed of 2724 subjects enrolled in the cardiovascular genome center. There were 728 patients with significant CAD. The different criterias of the MetS was applied for the study populations. Result: Among 2724 participants, 522(19.2%) met the NCEP criteria, 796(29.2%) met the a-NCEP criteria, 361(13.3%) met the WHO criteria, 576(21.1%) met the a-WHO criteria. The clinical parameters, lipid profile, apoA1 and apoB level were not different between the participants classified as MetS by using different criteria. The odds ratio for CAD prediction were not significantly different according to the metabolic criteria(Odd ratio: 1.755 [95% CI; 1.423-2.163] in NCEP criteria, 2.120 [1.763-2.549] in a-NCEP criteria, 1.854 [1.466-2.343] in WHO criteria, 2.205 [1.810-2.687] in a-WHO criteria). The serum level of apoA1 and apoB showed strong correlations with MetS classified by all criteria and the HOMA index and insulin level showed better correlations with WHO-MetS criteria. Conclusion: All the MetS criterias showed similar metabolic profiles and the ability for CAD prediction were similar between the 4 criterias. Conventional MetS criteria, applied to non-diabetic Asian population, may underestimate the population at risk. Our data suggests that the Asian modified criteria will decrease the risk for underdiagnosis while demonstrating similar metabolic profiles and CAD risk compared to the conventional criterias.