Background: Structural abnormalities of heart and cardiac dysfunction have been described in patients with liver cirrhosis. Condition with defective myocardial contractility under physical and pharmacological strain with liver cirrhosis is called cirrhotic cardiomyopathy. The aim of this study was to consider hemodynamic and cardiac function of cirrhosis and to evaluate the levels of pro-brain natriuretic peptide(pro-BNP) and their relationship with cardiac parameters. Methods: The study population comprised 30 patients with cirrhosis, without cardiac and pulmonary symptoms; 17 of the patients had ascites and 13 did not. The subjects underwent blood pressure, EKG, trans-thoracic two-dimensional echocardiography. Ankle-brachial index(ABI), brachial-ankle pulse wave velocity(baPWV) were also measured. Levels of pro-BNP were measured. The results were compared with those from 15 age-and sex-matched healthy controls. Results: Compared with controls, upper and lower mean arterial pressure were decreased in ascitic patients (p<0.05). Left atrial diameter and left ventricular end-diastolic diameter increased in cirrhotic group (p<0.05). Baseline Ejection fraction was increased in cirrhotic group (p<0.05). Prolonged deceleration time and lower E/A ratio were observed in cirrhotic group (p<0.01). A Level of pro-BNP was higher in all patients with cirrhosis with ascites (p<0.01). A level of pro-BNP was correlated with left atrial diameter (p=0.022, r=0.340) and left ventricular end diastolic diameter (p=0.038, r=0.310). Conclusion: Cirrhotic patients showed high pro-BNP level, low BP, increased LA size, prolonged DT, decreased E/A ratio. We conclude that elevated level of pro-BNP is related to LAD and LVEDD and level of pro-BNP may prove as a marker for cirrhotic cardiomyopathy.