Purpose;High-sensitivity C-reactive protein (hs-CRP) has been recognized as a very useful and sensitive predictor of the future risk of myocardial infarction. But the clinical significance of hs-CRP in children remains uncertain. To confirm the existence of obesity - induced vascular inflammation and the association between metabolic syndromes and elevation of CRP in children, we investigaed the relationship among CRP, obesity, BP, and serum lipids in schoolboys.
Methods:38 obese (BMI 29.61±3.29) and 93 non-obese (BMI 18.99±2.21) boys aged 14 years were examined. Serum CRP levels was measured by the high sensitive latex turbidimetric immunoassay and subjects with CRP levels below 0.3mg/dL were adopted to avoid the influence of acute infection. Comparison of serum CRP levels, BP, and serum lipids levels between obese and non-obese groups were performed.
Results:Obese children had significantly higher hs-CRP levels than non-obese group (0.104±0.075 vs. 0.054±0.005). In obese group, BMI, systolic BP (127.64±14.03 vs. 117.21±11.49), diastolic BP (83.21±9.86 vs. 75.57±7.17), apolipoprotein B(ApoB) (40.96±21.04 vs. 30.63±12.56), low density/high density lipoprotein cholesterol(LDL-C/HDL-C) (1.87±0.50 vs. 1.48±0.41), and triglyceride(TG) (144.89±80.47 vs. 105.32±65.29) were significantly higher than in non-obese. The BMI(r=0.480), diastolic BP(r=0.243), apolipoprotein E(ApoE)(r=0.270), and TG(r=0.359) showed positive correlation with log CRP by simple regression.
Conclusion:This study reveals a significant relationship between CRP and obesity in children. In addition, obese children tended to have high CRP levels, BP elevation and dyslipidemia. These results support the findings that CRP is one of the useful idices of childhood obesity that would affect the progression to future atherosclerotic disease.
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