BACKGROUND: Diastolic left ventricular(LV) function both in patients with concentric LV hypertrophy(LVH) and in aortic banded mice has been reported, but noninvasive evaluation of global cardiac function using myocardial performance(Tei) index in murine model has not been well described. The aim of this study was to assess global LV function using Tei index and to determine the feasibility of Tei index in both human and mice. METHODS: Forty hypertensive patients with concentric LVH on echocardiogram(Echo) and 20 healthy age- and sex-matched healthy controls were taken Echo. Fifteen ascending aortic banded male mice over 2 weeks and 10 age-matched sham-operated controls were studied using Echo with 15 MHz linear transducer including pulsed Doppler of mitral inflow and aortic outflow from the parasternal long axis view. RESULTS: The LV Tei indices both in human with concentric LVH and in aortic banded mice were significantly higher than controls. To test the diagnostic performance of Tei index to detect concentric LVH, we performed ROC curve analysis. Cutoff value of LV Tei index >0.44 in human had sensitivity 65% and specificity 95%, and cutoff value >0.49 in mice had sensitivity 100% and specificity 87.5%. CONCLUSION: The Tei index was a simple, noninvasive, and feasible Echo parameter to evaluate the global cardiac function both in patients with concentric LV hypertrophy(LVH) and in aortic banded mice.