학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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THE DIFFERENCE OF LEFT VENTRICULAR HYPERTROPHY AND DIASTOLIC FUNCTION BETWEEN PREHYPERTENSIVES AND NORMOTENSIVES
경희대학교 의과대학 순환기 내과학교실
안효석, 김수중, 김명곤, 조정휘, 김권삼, 송정상, 배종화
Objective: The seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure(JNC 7) has introduced a new classification that includes the term “prehypertention” for those with blood pressure(BP) ranging from 120 to 139 mm Hg systolic(SBP) and/or 80 to 89 mmHg diastolic blood pressure (DBP) to identify those individuals in whom early intervention by adoption of healthy lifestyles could reduce BP, decrease the rate of progression of BP to hypertensive levels with age, or prevent hypertension entirely. We investigated whether prehypertensives(PH) have more prevalent electrocardiographic and echocardiographic left ventricular hypertrophy (ECG LVH) and are more associated with impaired left ventricular(LV) diastolic function than normotensives(NT). Subjects and Methods: A total of 166 with normal BP (SBP<120 mmHg and DBP<80mmHg) and PH (n=136) without history of hypertension, diabetes, or any other known cardiovascular diseases were undertaken blood sampling for lipid profile, electrocardiography and echocardiography. Results: Compared with NT, PH had significantly higher Sokolow-Lyon and Cornell voltage for ECG LVH and with higher ECG LVH prevalence(3.6% vs 10.3%, 0.6% vs 4.4% respectively) than NT. PH had more increased left ventricular mass index(LVMI) and more decreased LV diastolic function in echocardiography than NT(table 1). Conclusions: PH were associated with higher prevalence of ECG LVH and more increased LVMI in echocardiography. Thus we should pay earlier attention to diagnose and screen PH group as mentioned in JNC 7 reports.

Table 1. Echocardiographic data in PH and NT.

PH (n=136)

NT(n=166)

? p

LV mass index (g/m2)

117.5 ± 26.4

101.9 ± 30.7

0.04

E/A ratio

1.25 ± 0.5

1.14 ± 0.6

0.03

DT (ms)

197.2 ± 10.2

190.5 ± 9.8

0.41

IVRT (ms)

88.5 ± 19.6

80.1 ± 14.2

0.04

E (cm/s)

8.4 ± 1.7

8.4 ± 1.9

0.93

A (cm/s)

9.6 ± 2.0

6.9 ± 1.9

0.02

DT, deceleration time; IVRT, isovolumic relaxation time



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