Purpose:The purpose of this study was to examine the relationship between depression and resilience and to identify the variables associated with depression among adolescents with congenital heart disease(CHD). Method: The resilience scale (cronbach���s 慣=.92), the Children's Depression Inventory (cronbach���s 慣=.72), the Parental Bonding Instrument (cronbach���s 慣=.88) were administered to 231 adolescents with congenital heart disease(CHD) under observation following open-heart surgery in three major cardiac centers. Mean adolescent age was 15.8yrs (range:13~18yrs), including 114 males and 117 females. Illness severity by cardiologist rating used CHD functional index and NYHA functional class. Results: The mean score for depression was 16.74 (range: 0-54) and for resilience, 115.84 (range: 32-128). There was a significant positive relationship between depression and three variables: age (r=.25, p<.001), NYHA functional class (r=.45, p<.001), and CHD functional index (r=.28, p<0.05). A negative relationship was found between depression and oxygen saturation (r=-.39, p<0.001) as well as academic achievement (r=-.41, p<.001), parental attitude (r=-.49, p<.001), and resilience (r=-.59, p<.001). Multiple regression analysis also showed that depression of adolescents with CHD was explained by 62 % of resilience (棺=-.62, p<0.05) and parental attitude(棺=-.48, p<0.05). Conclusion: This study demonstrated that adolescents with higher resilience together with an affectionate parent were less depressed. With respect to nursing intervention programs, it is essential to identify the strengths of adolescents with CHD in order to increase resilience. Additionally, it is important that parenting and counseling programs be implemented for the parents of these adolescents.