Background Drug-eluting stent (DES) may be effective in chronic total occlusion (CTO). However, there are little data about CTO intervention with DES. This study was performed to assess Immediate and one-year clinical outcome after DES implantation in CTO. Method Seventy-four patients underwent PCI for CTO were enrolled in this study from July 2002 to May 2005. Among them, thirty-nine consecutive patients were treated in DES (Cypher in 18 patients, Taxus in 20 patients, and both in 1 patient). Patients underwent 6-month follow-up angiography after 6 months and were followed clinically for 12months. We evaluated the immediate and one-year clinical outcome including death, myocardial infarction (MI), and target lesion revascularization (TLR). Results The lesion length was 43.73짹14.76 mm. The stents per lesion used was 1.5. No patients experienced in-hospital major adverse cardiac events (MACE) including death, MI, TLR. The 6-month angiographic follow-up study underwent in 66% of patients. The angiographic restenosis occurred in 11% (3/26). During 1-year follow-up period, one patient (2.5%) suffered death. None of patients experienced MI and TLR. The one-year MACE-free survival rate was 97.5짹 2.2%. Conclusion The immediate result and one-year clinical outcome after the use of DES for CTO is favorable.