Background: The early and late outcomes of multiple overlapping drug-eluting stents (DES) over a diffuse long de novo coronary lesion have not been elucidated. We investigated the 6-month angiographic and clinical outcomes of patients (pts) who underwent percutaneous coronary intervention (PCI) with multiple overlapping DES in a single coronary artery. Methods: All pts who were electively treated with long DES more than 60-mm were enrolled. All pts received aspirin, clopidogrel (300-600 mg) and cilostazol as the triple antiplatelet regimen. The unfractionated heparin (UFH; 50 IU/Kg) was given during the PCI and glycoprotein IIb/IIIa inhibitors were used on physician's discretion. Six month angiographic outcomes, early and mid-term clinical outcomes were evaluated. Results: A total 31 coronary arteries of 26 pts (male 16, 64.6짹11.4 years) were treated with sirolimus-eluting stents (SES; Cypher, 4/31 lesions, 12.9 %), paclitaxel-eluting stents (PES; Taxus, 24/31 lesions, 77.4 %), SES plus PES (2/31 lesions, 6.5 %) or bare metal stent (BMS) plus PES (1/31 lesions, 3.2 %), respectively. Diabetes mellitus was present in 7/26 pts (26.9 %). The target lesions were 58.1 % in the right coronary artery, 38.7 % left anterior descending artery and 3.2 % left circumflex artery. Total number of stents implanted per artery was 3.2 짹 0.9. The mean total stent length per artery was 83.1짹16.4 mm. Angiographic and procedural success was achieved in all patients. There were no in-hospital deaths, Q-wave myocardial infarction (MI), urgent bypass surgery, or repeat PCI and major adverse cardiac events (MACE) and these benefits were well maintained up to 6 months except 1 target lesion revascularization (TLR, 6.5 %, 2/31 lesions). At 6 months, two pts showed angiographic binary restenosis (In-stent restenosis type Ic,II, 7.7 %, 2/26 pts) requiring TLR. Conclusions: 'Full Metal Jackets' by multiple overlapping DES implantation over a very diffuse long de novo coronary lesion appears to be safe and effective up to 6 months.