This work was supported by a grant of Ministry of Health and Welfare, Republic of Korea (00-PJ6-PG5-23-0001) Backgrounds: AGEs–RAGE interaction in vessel wall may lead to inflammation, smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal hyperplasia and restenosis. Many polymorphisms in the RAGE gene have already been identified in diabetes or coronary artery disease, but their association with development of neointimal hyperplasia and in-stent restenosis after coronary artery stenting was not known. We investigated the possibility that single nucleotide polymorphisms of the genes encoding RAGE are associated with in-stent restenosis after coronary stenting. Methods: Our study included 334 consecutive non-diabetic patients with symptomatic coronary artery diseased who underwent bare metal stent implantation. Follow-up angiography was performed in 297 patients (88.9%), six months after intervention. We screened the -1106 T/C, -443 T/C, -388 T/A, -257 G/A, +557 G/A and +1704 G/T RAGE polymorphism in these patients. Genotyping was performed by PCR fragment-length polymorphism assay. Results: A total of 355 target lesions were evaluated, in 297 patients. There was no significant association of the -1106 T/C, -443 T/C, -388 T/A, -257 G/A, +557 G/A and +1704 G/T polymorphism with in-stent restenosis after coronary artery stenting. The distributions of the dominant genotypes were: 51.5% -1106TT; 77.8% -443TT; 65.7% -338TT; 90.6% -257GG; 75.1% +557GG; 68.0% +1704GG. We did not observe a significant difference in minimal luminal diameter(mm), late lumen loss(mm), loss index, diameter stenosis(%), and the rates of angiographic restenosis(%) in these polymorphisms. In a multivariate analysis of angiographic restenosis, we examined the possible influence of the baseline, lesion-related, and procedural variables. The multivariate analysis did not reveal an association of polymorphism with angiographic restenosis. Conclusion: Our observation suggests that the RAGE gene polymorphism is not associated with in-stent restenosis after coronary artery stening in non-diabetic patients. Keywords: In-stent restenosis, RAGE, polymorphism