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The Magnetocardiography Finding of Brugada Syndrome Different from Normal and Right Bundle Branch Block
Cardiology division, Severance Cardiovascular Center, Yonsei University Medical College, Seoul, Korea, Biomagnetism Research Center, Korea Research Institute of Standards and Science¹
Boyoung Joung, Yong-Ho Lee¹, Kiwoong Kim¹, Joung-hoon Sung, Jong-youn Kim, Moonhyoung Lee, Sungsoon Kim
Background: The differential diagnosis of Brugada syndrome remains a clinical challenge. Magnetocardiography(MCG) is a noninvasive method for the recording of cardiac electromagnetic signals at multiple sites above the chest cage. The present study aimed to analyze the diagnostic value of a 62-channel MCG for the detection of Brugada syndrome. Methods: The study included MCG data in 19 patients: 3 patients with Brugada syndrome, 8 RBBB patients with structurally normal heart and 8 healthy subjects. Twelve-lead ECG was obtained in all subjects. The MCG recordings were taken from 36 positions at rest. From these, magnetic field and current density vector(CVD) maps were generated every 10 ms from T wave end(Te) to T wave peak(Tp). Each map was then classified to dipole or nondipole pattern. With CVD map, the number of wavefronts vortexs was counted. Results: The QT interval and Qpeak-T interval by MCG was not significantly different among groups. Nondipolar pattern was not observed from Te-40ms to Te-60ms in normal and RBBB. However, 2 out of 3 patients with Brugada syndrome had nondipolar pattern. The number of wavefronts vortexs from Te-40ms to Te-60ms was significant higher in Brugada syndrome than normal and RBBB (Table). Conclusion: MCG finding of Brugada syndrome showed the dispersion of repolarization, which was different from normal and RBBB with structurally normal heart. MCG might be an additional noninvasive tool for the diagnosis of Brugada syndrome.

Time

Number of wavefronts vortexs (n)

p-value

Normal

RBBB

Brugada

Brugada-RBBB

Brugada-normal

RBBB-normal

Te

5.4±1.2

5.4±1.1

5.3±1.3

0.94

0.59

0.53

Te-10ms

4.4±1.7

4.1±1.0

4.5±0.5

0.64

0.89

0.65

Te-20ms

3.0±0.9

3.9±0.7

4.2±0.8

0.59

0.05

0.04*

Te-30ms

3.1±0.9

3.2±0.7

4.2±0.3

0.06

0.04*

0.73

Te-40ms

2.4±0.6

2.3±0.4

3.5±0.3

0.01*

0.02*

0.08

Te-50ms

2.4±0.6

2.3±0.4

3.5±0.5

0.003*

0.04*

0.80

Te-60ms

2.1±0.2

2.3±0.4

3.2±1.0

0.02*

0.01*

0.61



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