Purpose : To exhibit various imaging of CT perfusion and to assess the diagnosotic accuracy of 16-slice multidetector computed tomography of the occlusive rat myocardial infarction in the assessment of myocardial perfusion and viability Materials and Methods : To evaluate this study, author used 15 rats with thoracotomy and ligation of left anterior descending coronary artery distal to first diagonal artery. We performed a series of enhanced CT in rats that undergo 20 minutes of occlusion followed by 5 minutes. Five rats were als re-examined in one week late. Occlusive myocardial infarcted hearts were extirpated. After CT scanning, rats were sacrified for 2,3,5-triphenyltetrazolium chloride (TTC) histochemical staining. A stained slices was compared with CT imagings. Results : The perfusion defects seen at perfusion CT scan showed larger area than unstained areas at TTC staining. However, the size of the perfusion defect at perfusion CT correlated well with the sizes of unstained areas at TTC staining (r=0.75). Conclusion : In the rat model, the perfusion defected area on CT overestimated the true size of occlusive myocardial infarction and represents the area underwent irreversible myocardial damages.