Backgrounds: Contrast echocardiography (CE) improves left ventricular (LV) endocardial border delineation. However, the ���blooming��� artifact by the contrast agent (CA) may affect the value of the echocardiographic parameters. This study was aimed to find out whether echocardiographic variables measured with CE differ from those measured with conventional echocardiography. Methods: Two-dimensional echocardiographic test were performed in 25 subjects (M:F=19:6, 65짹9 years) with normal cardiopulmonary function before and after intravenous bolus injection of 3mL perfluorocarbon-exposed sonicated dextrose albumin (PESDA). At midventricular level of the parasternal short axis view, wall thickness of 4 segments (anteroseptal, inferoseptal, anterolateral and posterolateral wall) and anteroposterior diameter (APD) of LV cavity were measured at end-diastole. LV volume and ejection fraction (EF) was obtained by the modified Simpson���s method. LV mass was determined by multiplying LV muscle volume with the specific density of myocardium (1.05 g/ml). Echocardiographic variables measured before CA injection were compared with those after CA injection. Results: Wall thickness of 4 segments and LV mass were smaller on CE compared to those on conventional imaging (p<0.001). Meanwhile, LV APD (p<0.001), LV end-diastolic volume (p<0.001), and LV end-systolic volume (p=0.003) were higher on CE (table). There was no difference in LVEF between two methods. Intra-and inter-observer variability of each parameter was improved on CE compared to conventional imaging (p=0.005). Conclusion: Although contrast echocardiography reduces intra- and inter-observer variability, it may cause significant difference in LV cavity size, wall thickness, LV volume and mass compared to conventional echocardiography. Therefore, it should be put into consideration when performing contrast echocardiographic examination.