Background: Efforts should be aimed at helping patients with heart failure to facilitate self-care. The purpose of this study was to identify effects of the self-management program on physical and functional status, health perception, and quality of life (QOL) of patients with CHF. Methods: Forty-five patients (intervention: 21, control: 24), with HF as in a clinical judgment by Framingham criteria and echocardiographic findings; EF<50% were enrolled. Physical status measuring the presence and severity of symptoms and health perception measuring perceived health status of patients were investigated with questionnaires developed by researcher. Functional status was measured with Korean Activity Scale/Index (KASI). QOL was measured with Minnesota Living with Heart Failure Questionnaire (LHFQ). The intervention group received the self-management program and the control group received a conventional education during admission. Data were collected on the 3rd day of admission, 1 month and 3 months after discharge. Results: The baseline demographic (age: 60.1짹12.5, 66.7짹10.5, gender (M/F): 71:29, 58:42) and clinical data (ischemic/non-ischemic etiology: 38:62, 58:42), the presence and severity of symptoms, functional status, health perception, and QOL were similar in both groups. There was a significant difference in the presence of symptoms (27.3짹7.6 vs. 32.1짹7.4, p=0.04, 26.8짹8.0 vs. 32.0짹6.5, p=0.02), functional status (39.5짹16.3 vs. 29.7짹15.0, p=0.04, 40.1짹14.4 vs. 30.1짹17.7, p=0.04), and health perception (3.3짹0.7 vs. 2.7짹1.0, p=0.03, 3.3짹1.0 vs. 2.6짹0.9, p=0.02) between the intervention and control groups at 1 month and 3 months follow-up. Although there was no significant difference in QOL at 3 months follow-up, the intervention group reported better QOL than the control group (36.1짹14.9 vs. 43.3짹11.0, p=0.07). Conclusions: By facilitating self-management of CHF using tailored interventions such as various education programs and telephone monitoring, it is expected that patients are able to monitor their symptoms routinely, adhere to therapeutic regimen, and have an increase in QOL.