Backgound: The criteria in choosing the site for central venous access in infants may be different from adults or children: First, central venous cannulation in infants is technically more demanding, thus success rate can be the most important factor. Second, it carries higher incidence of complications that are more serious. Third, they have different anatomical features(1,2). This study was performed to compare the relative rate of success and complications between different sites of central venous catheterization in infants. Methods:In 272 infants, central venous catheterization was randomly tried on one of the four veins: right subclavian (RSCV), right internal jugular (RIJV), left subclavian (LSCV) or left internal jugular vein (LIJV). Results: In 77.2% of the patients, we successfully introduced a catheter at the first attempt. The rate of successful catheter placement was highest in RIJV (RIJV =88.2%, LIJV=79.4%, RSCV=67.7% and LSCV=55.9%; P < 0.01). In regard to complication, the rate of arterial puncture, guide wire advancement failure, and mal-position were all significantly frequent in SCV catheter (SCV vs IJV; 10.1% vs 2.1%, 12.4% vs 0%, and 13.4% vs 0.6%, respectively; P < 0.01, each). Conclusion:Our results imply that IJV, especially RIJV, should be the first choice for central venous catheterization in infants. Reference: 1.Cobb LM, Goss JC, Gilsdorf RB. Regional anatomy regarding the placement of central catheter in infants. 2.Cobb LM, Vinocur CD, Wagner CW, et al. The central venous anatomy in infants. Surg Gynecol Obstet 1987; 165:230-234entral venous cannulas. Ariz Med 1981; 38:33-36