Background and Purpose: Compression or closure devices have been used to enable rapid mobilization, patient���s comfort and early discharge after transradial coronary procedure (TRCP). There was no data comparing radial access using closure pad with compression device to standard hemostatic method. Methods: A total of 265 consecutive patients who required either coronary angiography or ad hoc coronary angioplasty via the radial artery was assigned to 3 groups; Group 1: manual compression with gauze packing in 63 cases, group 2: mechanical compression with TR band��� (Terumo Co, Japan) in 106 cases, group 3: Clo-Sur P.A.D��� (Medtronic AVE, Santa Rosa, CA) with TR band��� in 96 cases. We evaluated the incidence of local complication, total compression time and the pain scale of compression site. Local complication was classified as any bleeding or hematoma, pulse loss and skin rashes. Results: There was no difference in age, clinical diagnosis, the proportion of angioplasty patients, right or left radial approach and the size of arterial sheath among the 3 groups. The local complications rate (group 1: 9%, group 2: 13%, group 3: 1%, p <0.01), mean compression time (group 1: 10.5 + 5.3 hours, group 2: 6.1 + 4.0 hours, group 3: 3.3 + 1.2 hours, p < 0.01) and pain scale of compression site ( group 1: 2.2 + 0.5, group 2: 2.6 + 0.5, group 3: 1.8 + 0.5, p < 0.01) were significantly lowered in group 3 comparing to group 1 and 2. Conclusions: The use of Clo-Sur P.A.D��� with TR band��� was effective in reducing vascular complication, hemostatic time and the pain of compression site after TRCP