Purpose: We are reporting our experience with 25 patients diagnosed with Takayasu���s arteritis (TA) who underwent angioplasty and stenting in various vascular territories. Methods: From January 1998 to June 2003, 25 patients with TA ( 3 men, age 37.8 짹 15.5 years ) were treated with endovascular technique. The patients with active disease, defined as increase in inflammatory markers such as ESR, were administered with preinterventional immunosuppressive agents. Angioplasty was performed after ESR had been normalized. Angioplasty was carried out in patients with symptomatic lesion or with a hemodynamically significant aortic narrowing. Results: Of the 25 patients, 58 vascular territories were treated with angioplasty with( 39 lesions ) or without stenting ( 19 lesions ) : 7 aortic, 9 carotid, 3 verterbral, 11 subclavian, 2 superior mesenteric, 18 renal, 4 iliac and 4 coronary artery lesions. The mean level of the ESR when the vascular lesions were initially diagnosed was 35.6짹26.2 mm/hr, which fell to 18.5짹7.8 mm/hr after the immunosuppressive therapy. The procedure was performed successfully in 52 of 58 lesions(90%). During the follow-up period (mean 23.7 짹 18.4 months), restenoses occurred in 9 vascular lesions(17%). Four of these lesions were treated with repeated angioplasty. The overall cumulative primary clinical success rate was 82%, and secondary clinical success rate was 90%. Conclusions: Endovascular therapy for stenotic lesions in patients with TA is a safe and effective when disease activity is strictly controlled with immunosuppressive treatment.