OBJECT: The purpose of this study was to compare the concentration of hs-CRP in between variant angina pectoris (vAP) patients and disease free normal persons. Background; Main cause of chest pain in vAP is vasospasm. However, it is considered that most spastic coronary segments have minimal CAD. Therefore coronary inflammation seems to play an important role in vAP also. So far, the study of coronary inflammatory marker, hs-CRP in vAP has not been common. METHODS: One hundred thirty three vAP patients have been diagnosed with ergonovin (ERG) provocation coronary angiography (CAG)(n=71,51.4%) and ERG stress echocardiography (n=67,48.6%). Fixed CAD (> 50% of diameter stenosis) was ruled out in ERG provocation CAG group with normal or minimal CAG result and in ERG stress echocardiography group with negative result of treadmill test, thallium scan, or normal or minimal CAG result. Age, sex matched control (n= 111) who has no history of any angina like chest pain was randomly selected from health care screening department. The control has no diabetes mellitus, hypertension, hypercholesterolemia, current systemic infection, and elevated SGOT/SGPT. Hs-CRP concentration was checked by immuno Nephelometry in two groups and the mean of hs-CRP was compared. RESULTS:please see the table. CONCLUSION: hs-CRP level was significantly higher in vAP compared to control and was still higher in vAP without DM, HNT, hypercholesterolemia, and smoking. VAP without minimal CAD also had higher hs-CRP compared to control. Therefore, coronary inflammation might have a crucial role in the pathophysiology of vAP.