[Background] The reliable non-invasive detection of coronary artery disease is a prime goal for future developments in cardiology. In addition to the diagnosis of high-grade stenosis, the detection of vulnerable plaques is of major importance for early treatment to prevent plaque rupture leading to the development of acute coronary syndrome. We investigated the usefulness of Multi-Detector Row Spiral Computed Tomography (MDCT) for detection of vulnerable plaque in coronary artery.[Methods] Both MDCT(Sensation 16, Siemens, Germany, 16��0.75mm collimation, 0.375s rotation speed, 120kV, 500 effective mA, 3 mm/rotation table-feed) and coronary angiography with intravascular ultrasound (IVUS) were performed in several patients. Among these, we report two cases with the typical and same findings of vulnerable plaque in both MDCT and IVUS.[Results] Case one (Female, 76 years old, unstable angina) 1) MDCT finding : The value of HU (Hounsfield Units) of vulnerable plaque (ROI, Region Of Interest) in the mid-left anterior descending artery (LAD) was -30. This finding means lipid rich plaque. 2) Coronary Angiogram finding : There was 70 % luminal narrowing at mid-LAD. 3) IVUS finding : There was significant amount of hypoechoic mass indicating fibrofatty plaque at m-LAD. The minimal luminal area (MLA) was 2.9 mm2 and area of stenosis (AS) was 78%. Case two (Male, 57 years old, Myocardial infarction) 1) MDCT finding : The value of HU (Hounsfield Units) of vulnerable plaque (ROI, Region Of Interest) in the proximal-left anterior descending artery (LAD) was -50.This finding means lipid core. And multiple high density calciums were within the plaque. 2) Coronary Angiogram finding : There was hazziness at proximal-LAD. 3) IVUS finding : There was significant amount of hypoechoic mass indicating fibrofatty plaque. And there were multiple calcified lesions and a evidence of plaque rupture. The minimal luminal area (MLA) was 5 mm2 and area of stenosis (AS) was 90%. [Conclusion] The non-invasive technique of MDCT appears to be a useful method for detection of vulnerable plaque.