학술대회안내사전등록초록등록안내초록등록/관리숙박 및 교통
초록심사

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Effects of tadalafil citrate on signal transduction and hemodynamic parameters in the healthy young volunteers after treadmill exercise.
Department of Cardiology¹ and Urology², Chonbuk National University Medical School
Jae-Hyeong Park¹, Jong Kwan Park,² Hyun-Sook Kim,¹ Kyoung-Suk Rhee,¹ Jei Keon Chae,¹ Won Ho Kim,¹ Jae Ki Ko¹
Background: Tadalafil, a potent, selective, reversible phosphodiesterase 5 inhibitor for oral treatment of erectile dysfunction (ED), significantly improves erectile function in men with all degrees of ED severity. Its longer half-life can broaden its clinical applications, however it can increase the risk of developing adverse cardiovascular effects. We evaluated the acute effect of tadalafil on signal transduction of cardiovascular system and hemodynamic parameters in healthy subjects during treadmill exercise.
Subjects and methods: We included 10 healthy young volunteers without any cardiac problems. Tadalafil tablet (20mg) and placebo was given in a blind manner and sitting blood pressure (BP) and heart rate (HR) were monitored throughout the study. Transthoracic echocardiographic examinations were done and blood samples for the measurement of plasma cGMP, cAMP and plasma renin activity (PRA) were taken before and 2 hours after medication. Treadmill exercise was done 2 hours after medication in these participants with modified Bruce protocol. Just after about 20-minute exercise, echocardiographic examinations and blood sampling were done. Tadalafil and placebo groups were switched after four weeks and studies were done in the same manner.
Result: There was no significant difference in BP, HR, cardiac index, mitral inflow velocities and mitral annulus velocities at baseline and 2 hours after medication. BP, HR, and cardiac index were increased significantly after treadmill exercise in two groups compared with baseline levels, however, the difference in two groups was not significant. There was no difference in diastolic parameters. cGMP increased after treadmill exercise with tadalafil medication compared with placebo (14.0±2.3 vs 10.5±2.7 pmol/ml, p=0.007). PRA tended to increase after treadmill exercise with tadalafil medication (2.45±1.47 vs 1.40±1.27 ngAl/ml/hr, p=0.102)
Conclusion: Oral administration of tadalafil increased plasma cGMP concentration, especially after treadmill exercise. Despite of this increase, there was no significant difference in cardiac index, diastolic parameters, blood pressure and heart rates.


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