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ȣ - 480371 165 |
| The Risk of In-Stent Restenosis in Patients with Drug-Eluting Stent Implantation |
| Cardiovascular Medicine, Internal Medicine, Keimyung University College of Medicine |
| Chang-Wook Nam, Seung-Ho Hur, Kwon-Bae Kim, Young-Soo Lee, Jin-Hwa Jeon, Sang-Hoon Lee, Seong-Wook Han, Jung-A Gang, Kee-Sik Kim, Yoon-Nyun Kim |
BACKGROUND: Drug-eluting stents (DES) have been proven to strikingly decrease neo-intimal growth, leading to a marked reduction in restenosis rate, but restenosis still exist. The factors associated with the occurrence of restenosis after DES implantation are currently unknown. OBJECTIVES: This study aimed to evaluate the value of clinical, angiographic, and procedural factors in predicting the risk of binary restenosis in patients with DES implantation. METHODS: Since February 2003 to March 2004, 120 patients (180 lesions) who underwent follow-up coronary angiogram after DES implantation were divided into two groups by angiographic restenosis (≥50%) and analyzed. RESULTS: Mean follow-up duration was 9.5 months. At 6 months follow-up angiogram, 8.1% of lesions had binary in-stent restenosis. Clinical and PCI data are in the below table. Reference vessel diameter (RVD, CI 0.00 to 0.41; p=0.015) was independent multivariate predictors. CONCLUSIONS: Angiographic restenosis group after DES implantation had older age, smaller reference vessel diameter and post-PCI MLD. Reference vessel diameter was only predictors for ISR after DES implantation.
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Group
(n
= patient/lesion) |
Restenosis
(n = 11/14) |
No restenosis
(n = 109/166) |
p Value |
|
Male (%)
Age, yrs
Diabetes (%)
Hypertension (%)
SA/UA/AMI (%)
1/2/3 vessel disease
(%)
Pre-PCI
RD, mm
Pre-PCI MLD, mm
Lesion length, mm
Stent length, mm
Stent size, mm
Post-PCI MLD, mm |
63.6
63.4 ± 8.0
9.1
72.7
43.1/21.1/35.8
35.7/14.3/50.0
2.73 ± 0.46
0.45 ± 0.28
24.00 ± 12.81
26.92 ± 12.05
3.03 ± 0.14
2.80 ± 0.34 |
80.7
57.7 ± 10.6
13.8
43.1
36.4/27.3/36.4
22.3/41.6/36.1
3.05 ± 0.37
0.50 ± 0.28
19.64 ± 7.00
23.26 ± 6.20
3.08 ± 0.31
3.05 ± 0.42 |
0.171
0.041†
0.552
0.059
0.868
0.129
0.003†
0.496
0.248
0.299
0.408
0.026† |
SA; stable angina, UA; unstable angina, AMI; acute
myocardial infarction, PCI; percutaneous coronary intervention, RD; reference
diameter, MLD; minimal diameter, †; p value <
0.05
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