Background: In-stent restenosis (ISR) is an important limitation of the stent implantation. Silorimus-eluting stent (SES) lower the amount of intimal hyperplasia and significantly reduced restenosis after stent implantation. This stent also might have the potential to reduce neointimal proliferation and late lumen loss in restenotic lesions. We evaluated the effectiveness of SES implantation in ISR lesions. Method and results: Fifty eight consecutive patients who indicated to percutaneous coronary intervention for ISR were underwent SES implantation (ISR types : Focal 24, Diffuse 20, Total occlusion 4). There were no immediate procedural complications (death, MI or CABG). At 6 month follow up, there was no adverse cardiovascular events. There was one case of in-stent restenosis at a stent mid-portion. Angiographic binary restenosis was 5.5%. Angiographic findings were as below. Conclusions: SES stent implantation is an effective and efficient strategy for the for the treatment of ISR.