Background and aim: Paclitaxel eluting stents(Taxus) have been reported to be excellent in the terms of restenosis comparable with Sirolimus eluting stents(Cypher) in Europe and United States. MDR-1 gene encodes p-glycoprotein which is related to the Paclitaxel resistance and is known to have a few single nucleotide polymorphisms(SNPs). Therefore, we investigate the association between MDR-1 gene polymorphisms and Taxus restenosis. Methods: In 125 subjects(mean age: 60짹10 yrs, M/F:28:7)who were implanted with Taxus, 35 subjects had an angiographic follow-up at 6 months after stenting. Genomic DNA was isolated from whole blood, and after amplification via polymerase chain reaction(PCR), DNA sequencing for MDR-1 gene was performed. Binary restenosis was defined as diameter stenosis >50% on quantitative coronary analysis(QCA). Results: 1. Binary restenosis was observed in 12(35%) of 35 subjects and target lesion revascularization(TLR) was performed in 9(26%) subjects. 2. There were no significant differences in the prevalence of risk factors and stent diameters and stent lengths between restenosis and nonrestenosis group. 3. DNA sequencing of MDR-1 gene revealed nucleotide substitution 3435 C���T, 2677 G���T/A, respectively. 4. Although single polymorphisms were not associated with restenosis, the patients with genotype 3435TT/2677TT had increasing tendency to have Taxus restenosis compared with the patients with genotype 3435nonTnonT/2677nonTnonT(鍋²=3.64 ; P=0.056 ). Conclusion : Linkage of genetic polymorphism of MDR-1 gene at position 3435 and 2677 tends to be related with Taxus restenosis