Background: Results of bare metal stents (BMS) in the treatment of unprotected left main distal bifurcation lesions were discouraging because of higher angiographic restenosis (RS) and target lesion revascularization (TLR) rate. Recently drug-eluting stents (DES) are shown to decrease RS and TLR compared to BMS in various clinical subsets. Methods: Total 28 patients who were treated with BMS (n=16) or DES (n=12) were analyzed angiographically and clinically during 6 months follow-up. Results: Clinical baseline characteristics were comparable in both groups. Two stents were implanted in 9 patients with BMS and 3 patients with DES group. Before BMS, three debulking therapies including rotational and directional atherectomy were used. In DES group, 5 Cypher and 10 Taxus stents were implanted without debulking therapies. Simple cross over technique using one stent was more common in DES group (67% vs. 43.7% of BMS). Procedural success was 100% and in-hospital MACE was absent in both groups. In 6 months clinical follow-up, MACE (death/non-fatal myocardial infarction/TLR) was 38% (1/0/5) and 8% (0/0/1) in BMS and DES group, respectively (p=0.078). Conclusions: DES in the treatment of unprotected left main distal bifurcation lesions has a tendency of decreasing TLR rate compared to BMS in spite of a simple procedure. Angiographic results will be available on presentation.