Background: The aim of this study is to assess the in-hospital mortality and major adverse cardiac events (MACE) during long-term clinical follow-up in patients with cardiogenic shock (CS) after acute myocardial infarction (AMI) who underwent primary percutaneous coronary intervention (PCI). Methods and Results: We analyzed 147 patients with CS after AMI (61.7짹10.4 years, M:F=156:99), who admitted at Chonnam National University Hospital and underwent primary PCI between January 1999 and December 2002, according to clinical characteristics, coronary angiographic findings and mortality during admission and major adverse cardiac event (MACE) during 1-year clinical follow-up. Among the enrolled patients, 121 patients survived (Group I, M:F=94:27) and 26 patients died (Group II, M:F=14:12) during admission. In binary logistic regression analysis, in-hospital death was associated with low Thrombolysis In Myocardial Infarction (TIMI) flow after coronary revascularization (p=0.02, OR=1.3). Eighty- nine patients (60.5 %) survived without MACE during one-year clinical follow-up and MACE was associated with CRP more than 1mg/dL (p=0.002, OR=6.3) and low TIMI flow after coronary revascularization (p<0.001, OR=7.8). Conclusions: Primary PCI to obtain TIMI 3 flow lowers in-hospital death in AMI with CS. High level of CRP and low TIMI flow are associated with MACE during long-term clinical follow-up.