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ȣ - 480061 299 |
| Determinants of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with primary dilated cardiomyopathy |
| Department of medicine, Samsung medical center, Sungkyunkwan university school of medicine |
| Sung Uk Kwon, Seung Woo Park, Sang-Chul Lee, Jidong Sung, Sang Hoon Lee, Kyung Pyo Hong, Eun-Seuk Jeon |
Background
Measurement of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels has been used for the diagnosis of heart failure. However, major determinants of NT-proBNP in primary dilated cardiomyopathy (DCM) need to be elucidated. This study was aimed to characterize the echocardiographic variables to determine the plasma NT-proBNP levels in patients of primary DCM.
Methods
From the 83 patients with primary DCM without nephropathy (plasma creatinine level<1.5mg/dl), echocardiographic indices and grade of NYHA (New York Heart Association Functional Classification) were compared with plasma NT-proBNP levels which were measured within 2 weeks after echocardiographic examination. The relationship between the NT-proBNP levels and echocardiographic variables were analyzed.
Results
Baseline characteristics of the primary DCM patients are listed in Table 1. In multivariate analysis, LV EF (p=0.027), LVIDs (p<0.001), LVIDd (p<0.001), and tricuspid regurgitation (p=0.002) have significant correlations between ln[NT-proBNP] (p<0.001, R =0.706).
Conclusion
Plasma NT-proBNP level may be related both structural and functional change of LV in primary DCM.
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Table
1. Clinical and Demographic Characteristics of the Study Population (n
=83)
|
Age
(yrs) |
55.6
±
13.9 |
|
Gender
(M/F) |
56
/ 27 |
|
NT-proBNP
(pg/ml) |
677.6
(261.5, 1867)* |
|
LV
ejection fraction (%) |
33.9
±
13.3 |
|
LV
end-diastolic dimension / end-systolic dimension (mm) |
65.4
±
10.0 / 52.7 ±
11.9 |
|
LV
septal wall thickness / posterior
wall thickness
(mm) |
8.6
±
1.6 / 8.5 ±
1.7 |
|
LV
end-diastolic volume (ml) |
186.2
±
85.3 |
|
Severity
of valvular regurgitation and NYHA** (%) |
|
|
None/trace
[class I] |
32.5
/ 48.2 [2.4] |
|
Mild
[class II] |
20.5
/ 24.1 [53.0] |
|
Moderate
[class III] |
34.9
/ 18.1 [36.1] |
|
Severe
[class IV] |
12.0
/ 9.6 [8.4] |
|
*BNP
is given as a median value (25%, 75% quartiles) because it was not
normally distributed. All other values are expressed as number, percentage
or mean
±
1SD.
**New York Heart Association Functional Classification |
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