[Purpose] Traditionally right heart catheterization was done through the internal jugular, subclavian, or femoral vein. Transradial coronary angiography was well established in these days. In cases where both right and left heart catheterization was needed, cardiologists prefer the femoral approach rather than the radial approach. Femoral approach requires bed rest, risk of bleeding, hematoma and admission. So, we evaluated the feasibility of bilateral heart catheterization using the radial artery and antecubital vein for outpatients compared with conventional femoral approach. [Methods] 24 outpatients were performed the bilateral cardiac catheterization through the transradial artery and antecubital vein using the 6 Fr wedge balloon catheter and 5 Fr Judkins coronary diagnostic catheter. Procedure related success rate, complication and other results were compared with femoral approach. [Results 1) There was no significant difference in the rate of procedure success in patients through the radial and antecubital approach than the femoral approach (96.9 vs 100%). 2) There were no complications such as vascular dissection, transfusion requiring hematoma in the radial and antecubital group, but one hematoma was occurred in the femoral group. 3) Procedure time, flouroscopy time and catheter number were not difference between both group. 4) The hospital cost was lower in the radial group than the femoral group. [Conclusion] Bilateral cardiac catheterization and angiography through the ratial artery and antecubital vein were safely performed in the outpatient population. Our experience suggests that antecubital vein is a alternative access site in the case of need for right heart catheterization.